beta-Adrenoceptor antagonists and respiratory function.

Alpha- and beta-adrenoceptor antagonists.

Antagonists acting on the betaor alphaadrenoceptors are used widely in medicine and in anaesthesia. The major indications for betaadrenoceptor blockade are coronary artery disease and arterial hypertension, while those for alphaadrenoceptor blockade include arterial hypertension, paroxysmal hypertension and chronic cardiac failure. The adrenoceptor antagonists interfere with important regulator...

Adrenoceptor Antagonists

Drugs that produce responses by interacting with adrenoceptors are referred to as adrenoceptor agonists or adrenergic agonists. Norepinephrine and isoproterenol are examples of such compounds. Agents that inhibit responses mediated by adrenoceptor activation are known as adrenoceptor antagonists, adrenergic antagonists, or adrenergic blocking agents. Prazosin and propranolol are examples of rec...

TEACHERS’ TOPICS Antianginal Actions of Beta-Adrenoceptor Antagonists

Angina pectoris is usually the first clinical sign of underlying myocardial ischemia, which results from an imbalance between oxygen supply and oxygen demand in the heart. This report describes the pharmacology of b-adrenoceptor antagonists as it relates to the treatment of angina. The b-adrenoceptor antagonists are widely used in long-term maintenance therapy to prevent acute ischemic episodes...

Beta-adrenoceptor subtype expression and function in rat white adipocytes.

1. The pharmacological features of rat white adipocyte beta-adrenoceptor subtypes were investigated by saturation and beta-agonist competition studies with [3H]-CGP 12177 and by lipolysis induced by beta-agonists as well as their inhibition by CGP 20712A (selective beta 1-antagonist) and ICI 118551 (selective beta 2-antagonist) in an attempt to establish a relationship between the functionality...

Regulation of beta-adrenoceptor signaling in cardiac function and disease.